Faculty of Science - Professor Details | science

Faculty of Science

Derek PRATT

Derek PRATT
Rank/Status:
Associate Professor
Department:
Chemistry
Office:
DRO 308
Telephone:
(613) 562-5800 x2119
Fax:
(613) 562-5170
Email:
dpratt@uOttawa.ca
Home Page:
http://dpra24.wix.com/theprattgroup

Keywords:
Organic and Biological Chemistry
Bioorganic chemistry, mechanistic organic chemistry, synthetic organic chemistry, free radicals, antioxidants, lipid oxidation, molecular toxicology

Research Interests:
Dr. Pratt’s research group focuses on the chemistry of reactions believed to be at the root of the onset and development of degenerative diseases, such as atherosclerosis (heart disease), neurodegenerative disease (Alzheimer’s, Parkinson’s) and cancer. In particular, they are interested in the free radical oxidation of lipids, and the subsequent transformation of the lipid oxidation products to toxic small molecules. In parallel, the group studies the role of natural products believed capable of slowing these processes down (antioxidants) and also works to design and synthesize new compounds with improved efficacies. In fact, they have developed the most effective radical-trapping antioxidants known! The group is also interested in how Nature uses protein-derived and/or co-factor-derived radicals to catalyze reactions and carry out the energy conversion processes essential to life.

Selected publications:
  • Nara, S.J., Valgimigli, L., Pedulli, G.F., Pratt, D.A. Tyrosine analogues for probing proton-coupled electron transfer processes in peptides and proteins. Journal of the American Chemical Society, 132, 863-872, 2010
  • Nam, T.-G., Nara, S.J., Zagol-Igapitte, I., Cooper, T., Valgimigli, L., Oates, J.A., Porter, N.A., Boutaud, O., Pratt, D.A. Pyridine and pyrimidine analogs of acetaminophen: Inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis. Organic and Biomolecular Chemistry, 7, 5103-5112, 2009
  • Valgimigli, L., Amorati, R., Petrucci, S., Pedulli, G.F., Hu, D., Hanthorn, J.J., Pratt, D.A. "Unexpected" acid catalysis in the reaction of peroxyl radicals with phenols. Angewandte Chemie International Edition, 11, 8348-8351, 2009
  • Vaidya, V., Ingold, K.U., Pratt, D.A. Garlic: Source of the ultimate antioxydants - Sulfenic acids. Angewandte Chemie International Edition, 48, 157-160, 2009
  • Brinkhorst, J., Nara, S.J., Pratt, D.A. Hock cleavage of cholesterol 5g-Hydroperoxide: An ozone-free pathway to the cholesterol ozonolysis products identified in arterial plaque and brain tissue. Journal of the American Chemical Society, 130, 12224-12225, 2008